JWH-210

Systematic (IUPAC) name: 4-ethylnaphthalen-1-yl-(1-pentylindol-3-yl)methanone

Identifiers:

CAS number:

  • 824959-81-1 (JWH-210)
  • 619294-47-2 (JWH-122)

ATC code: ?

PubChem: CID 45270396

Chemical data:

Formula: C26H27NO

Mol. mass: 369.498 g/mol

JWH-210 is an analgesic chemical from the naphthoylindole family, which acts as a potent cannabinoid  agonist at both the CB1 and CB2  receptors, with Ki values of 0.46nM at CB1 and 0.69nM at CB2. It is one of the most potent 4-substituted naphthoyl derivatives in the naphthoylindole series, having a higher binding affinity (i.e. lower Ki) at CB1 than both its 4-methyl and 4-n-propyl homologues (JWH-122 and JWH-182 respectively), and than the 4-methoxy compound JWH-081. It was discovered and named after Dr. John W. Huffman.